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Molecule List for pathway Shared_Object_AMPAR_CaMKII_strong_coupling (Pathway Number 271) in Accession AMPAR_CaMKII_strong_coupling (Accession Number 64)

Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
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The entries are grouped according to Pathway Number and are alternately color coded using  and  color.
  NameAccession
Type
Initial
Conc.

(uM)
Volume
(fL)
BufferedSum Total Of
1 NMDARNetwork1200No
    The stochiometry is a bit off here. Each NMDAR actually binds to a holoenzyme, about 12 CaMKII subunits. But our CaMKII calculations are in terms of individual subunits. So as a hack, we put in much more NMDAR than is actually there.
2 AnchorNetwork27.33330No
3 tot_CaMKII_cytNetwork220No CaMKII-CaM
  •  CaMKII-thr286*-C
    aM

     CaMKII-thr286
     CaMKII***
     CaMK-thr305
     CaMKII
  •  basal_CaMKII_
    cyt

  • 4 PP1-active_PSDNetwork80No
        Cohen et al Meth Enz 159 390-408 is main source of info conc = 1.8 uM
    5 temp-PIP2Network2.50Yes
        This isn't explicitly present in the M&L model, but is obviously needed. I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim 7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs, which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984 Lets use a lower level of 30 nM, same ref....
    6 
  • basal_CaMKII_
    PSD
  • Network20No
    7 
  • basal_CaMKII_
    cyt
  • Network20Yes
    8 
  • basal_CaMKII_
    PSD_control
  • Network20Yes
    9 tot-auto-PSDNetwork20No
  •  CaMKII-thr286-PS
    D

     CaMKII***-PSD
  •  basal_CaMKII_
    PSD

  • 10 actCaMKII-PSDNetwork20No
  •  CaMKII-thr286-Ca
    M-PSD

     CaMKII-CaM-PSD
     tot-auto-PSD
  • 11 tot_CaMKII_PSDNetwork20No actCaMKII-PSD
     CaMKII-PSD
  •  CaMKII-thr305-PS
    D

  • 12 act_CaMKII_cytNetwork20No tot_CaM_CaMKII
  •  tot_autonomous_
    CaMKII

  • 13 PP1-activeNetwork1.80No
        Cohen et al Meth Enz 159 390-408 is main source of info conc = 1.8 uM
    14 PP2ANetwork0.11110No
    15 PKC-activeNetwork0.10No
    16 PKC-controlNetwork0.10Yes
    17 CaNetwork0.080No
    18 Ca-PSDNetwork0.080No
    19 Ca_control_cytNetwork0.080Yes
    20 Ca_control_PSDNetwork0.080Yes

     
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